Hannover Medical School (MHH)
The Hannover Medical School (MHH) is one of the worldwide leading hospitals for organ‐ and stem cell transplantation. Due to considerable transplantation programs and potential complication for the immune system connected to transplantation, research in the area of infection and immunity is the focus of the MHH. MHH is a tertiary medical referral center for patients with inter alia, cardiovascular, pulmonary and hepatic diseases as well as haematological disorders. MHH has an international reputation for stem cell and organ transplantation. The MHH is one of the pivotal partners of the Niedersächsische Wirkstoffzentrum, since it provides insight and expertise on medicinal needs and urgent scientific questions. As one of the leading transplantation centres in Europe, scientific questions in the context of infection are naturally of high priority. Besides scientific and medicinal expertise, the MHH provides state of‐the‐art facilities and services in the biomedicinal, biochemical and biophysical area.
Twincore is a translational centre, which closely links basic and clinical research. It is focused on the search for new strategies for the diagnosis, prevention and treatment of infectious diseases. A special focus is on microbes that are developing resistance to existing treatments and are a medicinal challenge worldwide. Tuberculosis, AIDS, hepatitis and malaria threaten millions of people and research groups at the Twincore investigate how pathogens and host cells interact with each other and how this interaction can be inhibited. Twincore provides translation from biological to medical research. It holds expertise in specific anti‐viral assays and scientific questions with respect to infection and immunity. Twincore provides the infrastructure for the analysis of pathogen‐host interactions, the identification of new mechanisms of pathogen inhibition, and new preclinical models.
Twincore also provides various unique opportunities to screen for natural products, e.g. as novel antiviral, immunomodulatory, and antimicrobial agents.
The Hannover Clinical Trial Center (HCTC)
The Hannover Clinical Trial Center (HCTC) is a international recognized partner for clinical research and development. It has expertise in planning and performing clinical studies for new drugs and medical products according to standards such as GCP or AMG. The chief asset of HCTC is the strong scientific background of its personnel and the interaction with Hannover Medical School (MHH), the Fraunhofer Institute for Experimental Medicine (ITEM) and the Helmholtz Centre for Infection Research (HZI). In combination with its clinical research experience and connections to regulatory agencies it is one of the most competent centers for clinical phase studies in Germany.
The Braunschweig Integrated Centre for Systems Biology (BRICS)
The Braunschweig Integrated Centre for Systems Biology (BRICS) is a joint interdisciplinary research centre of the TU Braunschweig and the Helmholtz Centre for Infection Research (HZI). These two institutions are linked by a shared research interest in combatting infections and developing active substances. The Leibniz institute German Collection of Microorganisms and Cell Cultures (DSMZ) is the third partner of BRICS. The scientists of BRICS are applying systems biology methods in order to discover novel strategies to counter infections, and establish biotechnological production methods for therapeutic agents. Their work is based on a state-of-the-art infrastructure for genome, transcriptome, proteome and metabolome analyses, along with bioinformatics tool development and expertise in quantitative modelling of biological systems. The systems biology approach enables holistic recording of the biology of the bacterium. Probably the most-used BRICS product is the BRENDA enzyme information system with more than 60,000 users per month. A new 3,500-square-metre building will host the BRICS on the central campus of the TU Braunschweig. From the end of 2015 on, seven research groups of biologists, chemists, physicists, mathematicians, computer scientists and various engineers will work there together on new interdisciplinary experimental and theoretical approaches. BRICS belongs to TRAIN, the translation alliance for Lower Saxony, and to the North German Center for Microbial Genomics.
Leibniz-Institut - Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH
The DSMZ is one of the largest biological resource centers worldwide. Its collections includes about 29,000 different bacterial and 5,000 fungal strains, 700 human and animal cell lines, 800 plant cell lines, 1,000 plant viruses and antisera, and 10,000 different types of bacterial genomic DNA. The DSMZ provides an extensive documentation and detailed diagnostic information on the biological materials. The unprecedented diversity and quality management of its bioressources render the DSMZ an internationally reknown supplier for science, diagnostic laboratories, national reference centers, as well as industrial partners.
The research of the DSMZ focuses on microbial diversity and the underlying evolutionary mechanisms (genome evolution, population genetics), improved methods for the access and ex situ preservation of biodiversity, as well as molecular mechanisms of biological interactions (symbioses, mechanisms of disease, cancer). By the use of innovative, high-throughput cultivation and isolation techniques, novel types of potential microbial producers are recovered from natural samples and subsequently genome-sequenced to determine their capacity for natural compound synthesis.