Publications at the BMWZ
2026
Korotkov, V. S., Lukat, P., Di Lucrezia, R., Shekhar, A., Degenhart, C., Diestel, R., Bilitewski, U., Dinkel, K., Blankenfeldt, W., & Brönstrup, M. (2026). An Imidazo[2,1-b][1,3,4]thiadiazole Derivative Inhibits the Virulence Factor α-Hemolysin by Blocking the Pullout of Its Stem Domain. CHEMMEDCHEM, 21(4), Article e202501098. https://doi.org/10.1002/cmdc.202501098
Kwan, B. D., Kim, T., Nguyen, H. H. T., Wang, J., Xia, Z., Franke, J., & Dang, T. T. T. (2026). Orthologue inference-based enzyme mining for diversification of the anti-cancer evodiamine scaffold. Communications Chemistry, 9(1), Article 73. https://doi.org/10.1038/s42004-025-01876-6
Seligmann, B., Liu, S., Huynh, M., Dang, T. T. T., & Franke, J. (2026). Production of the anticancer drug intermediate strictosidinic acid in engineered yeast. Journal of biotechnology, 415, 1-12. https://doi.org/10.1016/j.jbiotec.2026.03.017
Walbrunn, K. (2026). Structural determination of Entamoeba Histolytica TGT and its binding to tRNAASP. [Doctoral thesis, Leibniz University Hannover]. Leibniz Universität Hannover. https://doi.org/10.15488/20616
Xiao, C., Long, M., Sun, X., Yi, D., Miah, M. S., Yang, S., Ma, H., Tian, D., Cox, R. J., Zhang, X., & Zhang, B. (2026). Characterization and employment of novel α-ketoglutarate dependent oxygenases for efficient synthesis of antifungal alkyl citrates. Bioresource technology, 443, Article 133787. https://doi.org/10.1016/j.biortech.2025.133787
2025
Akula, R. K., El Kilani, H., Metzen, A., Röske, J., Zhang, K., Göhl, M., Arisetti, N., Marsh, G. P., Maple, H. J., Cooper, M. S., Karadogan, B., Jochmans, D., Neyts, J., Rox, K., Hilgenfeld, R., & Brönstrup, M. (2025). Structure-Based Optimization of Pyridone α-Ketoamides as Inhibitors of the SARS-CoV-2 Main Protease. Journal of medicinal chemistry, 68(3), 2920–2941. https://doi.org/10.1021/acs.jmedchem.4c02172
Beutling, U., Hotop, S. K., Frank, R., & Brönstrup, M. (2025). Facile High-Throughput Pre-purification of Biological Samples for Library-Scale Peptide Interaction Studies. In Methods in Molecular Biology (pp. 181-187). (Methods in Molecular Biology; Vol. 2934). Humana Press Inc.. https://doi.org/10.1007/978-1-0716-4578-9_13
Boudrioua, A., Joiner, J. D., Grin, I., Kronenberger, T., Korotkov, V. S., Steinchen, W., Kohler, A., Schminke, S., Schulte, J. C., Pietsch, M., Naini, A., Kalverkamp, S., Hotop, S. K., Coyle, T., Piselli, C., Coles, M., Rox, K., Marschal, M., Bange, G., ... Wagner, S. (2025). Discovery of synthetic small molecules targeting the central regulator of Salmonella pathogenicity. Science advances, 11(15), Article eadr5235. https://doi.org/10.1126/sciadv.adr5235
Brvar, M., O’Neill, T. J., Plettenburg, O., & Krappmann, D. (2025). An updated patent review of MALT1 inhibitors (2021–present). Expert Opinion on Therapeutic Patents, 35(6), 639-656. https://doi.org/10.1080/13543776.2025.2484371
Bui, V. H., Nguyen, T. A. M., Kim, T., Liu, S., Seligmann, B., Daneshgar, P., Nguyen, T. D., Zandberg, W. F., Franke, J., & Dang, T. T. T. (2025). Discovery of corynanthe synthases in Camptotheca acuminata: medium-chain dehydrogenase/reductase-based gateway to corynanthe-type compound diversification. PLANTA, 262(4), Article 80. https://doi.org/10.1007/s00425-025-04792-0
