Publications – Centre of Biomolecular Drug Research

Akula, R. K., El Kilani, H., Metzen, A., Röske, J., Zhang, K., Göhl, M., Arisetti, N., Marsh, G. P., Maple, H. J., Cooper, M. S., Karadogan, B., Jochmans, D., Neyts, J., Rox, K., Hilgenfeld, R., & Brönstrup, M. (2025). Structure-Based Optimization of Pyridone α-Ketoamides as Inhibitors of the SARS-CoV-2 Main Protease. Journal of medicinal chemistry, 68(3), 2920–2941. https://doi.org/10.1021/acs.jmedchem.4c02172

Boudrioua, A., Joiner, J. D., Grin, I., Kronenberger, T., Korotkov, V. S., Steinchen, W., Kohler, A., Schminke, S., Schulte, J. C., Pietsch, M., Naini, A., Kalverkamp, S., Hotop, S. K., Coyle, T., Piselli, C., Coles, M., Rox, K., Marschal, M., Bange, G., ... Wagner, S. (2025). Discovery of synthetic small molecules targeting the central regulator of Salmonella pathogenicity. Science advances, 11(15), Article eadr5235. https://doi.org/10.1126/sciadv.adr5235

Brvar, M., O’Neill, T. J., Plettenburg, O., & Krappmann, D. (2025). An updated patent review of MALT1 inhibitors (2021–present). Expert Opinion on Therapeutic Patents, 35(6), 639-656. https://doi.org/10.1080/13543776.2025.2484371

Ewert, W., Bartens, C., Ongouta, J., Holmes, M., Heutling, A., Kishore, A., Urbansky, T., Zeilinger, C., Preller, M., & Kirschning, A. (2025). Structure and function of the geldanamycin amide synthase from Streptomyces hygroscopicus. Nature Communications, 16(1), Article 2464. https://doi.org/10.1038/s41467-025-57013-3

Hakim, S. E., Liu, S., Herzog, R., Arafa, A., de Vries, J., Dräger, G., & Franke, J. (2025). Expansion of the Stereochemical Space of Triterpenes by Mining Noncanonical Oxidosqualene Cyclases Across the Diversity of Green Plants. Journal of the American Chemical Society, 147(12), 10320-10330. https://doi.org/10.1021/jacs.4c16956

Heimann, D., Kohnhäuser, D., Kohnhäuser, A. J., & Brönstrup, M. (2025). Antibacterials with Novel Chemical Scaffolds in Clinical Development. DRUGS, 85, 293–323. Article 115484. https://doi.org/10.1007/s40265-024-02137-x

Kirkpatrick, J. P., Karanth, M. N., & Carlomagno, T. (2025). NMR chemical shift assignment of the IMLV methyl groups of a di-domain of the Tomaymycin non-ribosomal peptide synthetase. Biomolecular NMR assignments, 19(1), 153-164. https://doi.org/10.1007/s12104-025-10231-8

Kishore, A., Varughese, A. M., Roth, B., & Zeilinger, C. (2025). Stress biomarker test for athletes with portable optical detector and functionalized quantum dots. In B. Shadgan, & A. H. Gandjbakhche (Eds.), Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables VI Article 133130A (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 13313). SPIE. https://doi.org/10.1117/12.3040893

Schmidt, K., Charria-Girón, E., Gorelik, T. E., Kleeberg, C., Muema, J. M., Heitkämper, S., Verwaaijen, B., Kuhnert, E., Gerke, J., Kalinowski, J., Hyde, K. D., Stadler, M., Cox, R., & Surup, F. (2025). Lienhwalides: Unique Tropolone–Maleidride Hybrids from Hypoxylon lienhwacheense. CHEMBIOCHEM, 26(10), Article e202500037. https://doi.org/10.1002/cbic.202500037

Shekhar, A., Di Lucrezia, R., Jerye, K., Korotkov, V. S., Harmrolfs, K., Rox, K., Weich, H. A., Ghai, I., Delhommel, F., Becher, I., Degenhart, C., Fansa, E., Unger, A., Habenberger, P., Klebl, B., Lukat, P., Schmelz, S., Henke, S., Borgert, S., ... Brönstrup, M. (2025). Highly potent quinoxalinediones inhibit α-hemolysin and ameliorate Staphylococcus aureus lung infections. Cell Host and Microbe, 33(4), 560-572.e21. https://doi.org/10.1016/j.chom.2025.03.006

Publications at the BMWZ

2025