Publications

Cox RJ, Wang C, Lambert C, Hauser M, Deuschmann A, Zeilinger C, Rottner K, Stradal T, Stadler M, Skellam E (2020): Diversely Functionalised Cytochalasins via Mutasynthesis and Semi-Synthesis. Chemistry
DOI: 10.1002/chem.202002241

Heard, David M., Tayler, Emyr R., Cox, Russell J., Simpson, Thomas J., Willis, Christine L. (2020): Structural and synthetic studies on maleic anhydride and related diacid natural products, TETRAHEDRON, 2020, 76
DOI: 10.1016/j.tet.2019.130717

Lukas Kahlert, Eman F. Bassiony, Russell J. Cox and Elizabeth J. Skellam (2020): Diels Alder Reactions During the Biosynthesis of Sorbicillinoids, Angewandte Chemie, 2020, in press

Marc Stadler, Christopher Lambert, Daniel Wibberg, Jörn Kalinowski, Russell J. Cox, Miroslav Kolařík, Eric Kuhnert (2020): Intragenomic polymorphisms in the ITS region of high quality genomes of the Hypoxylaceae (Xylariales, Ascomycota), Mycological Progress, 2020, in press
DOI: 10.1007/s11557-019-01552-9

Verena Hantke, Elizabeth J. Skellam, Russell J. Cox (2020): Evidence for enzyme catalysed intramolecular [4+2] Diels–Alder cyclization during the biosynthesis of pyrichalasin H., Chemical Communications

Berndt, V.; Beckstette, M.; Volk, M.; Dersch, P.; Broenstrup, M. (2019): Metabolome and transciptome-wide effects of the carbon storage regulator A in enteropathogenic Escherichia coli., Scientific Reports 2019, 9
DOI: 10.1038/s41598-018-36932

C. Greco, K. de Mattos-Shipley, A. M. Bailey, N. P. Mulholland, J. L. Vincent, C. L. Willis, R. J. Cox, T. J. Simpson (2019): Structure revision of cryptosporioptides and determination of the genetic basis for dimeric xanthone biosynthesis in fungi, Chem. Sci. 2019 in press
DOI: 10.1039/c8sc05126g
ISBN: 2930-2939

Hantke, Verena, Wang, Chongqing, Skellam, Elizabeth J., Cox, Russell J. (2019): Function of pathway specific regulators in the ACE1 and pyrichalasin H biosynthetic gene clusters, RSC ADVANCES, 2019, 9
DOI: 10.1039/c9ra07028a
ISBN: 35797-35802

Hermane J, Eichner S, Mancuso L, Schröder B, Sasse F, Zeilinger C, Kirschning A (2019): New geldanamycin derivatives with anti Hsp properties by mutasynthesis. Org Biomol Chem. 17, 5269-5278
DOI: 10.1039/c9ob00892f

Höhl M, Zeilinger C, Roth B, Meinhardt-Wollweber M, Morgner U (2019): Multivariate discrimination of heat shock proteins using a fiber optic Raman setup for in situ analysis of human perilymph. Rev Sci Instrum. 90, 043110
DOI: 10.1063/1.5030301

Kniggendorf AK, Schmidt D, Roth B, Plettenburg O, Zeilinger C (2019): pH-Dependent Conformational Changes of KcsA Tetramer and Monomer Probed by Raman Spectroscopy. Int J Mol Sci., 20, pii: E2736
DOI: 10.3390/ijms20112736

Krüger K, Reichel T, Zeilinger C (2019): Role of heat shock proteins 70/90 in exercise physiology, exercise immunology and their diagnostic potential in sports. J Appl Physiol. (1985), 126, 916-927
DOI: 10.1152/japplphysiol.01052.2018

Lebe, Karen E., Cox, Russell J. (2019): O-Methylation steps during strobilurin and bolineol biosynthesis, RSC ADVANCES, 2019, 9
DOI: 10.1039/c9ra06412e
ISBN: 31527-31531

Luebken, D.; Saxarra, M.; Kalesse, M. (2019): Tris(acetylacetonato) Iron (III): Recent Developments and Synthetic Applications., Synthesis-Stuttgart, 2019, 51(1), 161-177
DOI: 10.1055/s-0037-1610393

Marchanka, A.; Carlomagno T. (2019): Solid-State NMR Spectroscopy of RNA., Methods Enzymol. 2019, 615, 333-371
DOI: 10.1016/bs.mie.2018.08.029

Ozturk, I. Kutay, Dupont, Pierre-Yves, Chettri, Pranav, McDougal, Rebecca, Boehl, Ole J., Cox, Russell J., Bradshaw, Rosie E. (2019): Evolutionary relics dominate the small number of secondary metabolism genes in the hemibiotrophic fungus Dothistroma septosporum, FUNGAL BIOLOGY, 2019, 123
DOI: 10.1016/j.funbio.2019.02.006
ISBN: 397-407

Szwalbe, A. J.; Williams, K.; Song, Z.; de Mattos-Shipley, K.; Vincent, J. L.; Bailey, A. M.; Willis, C. L.; Cox, R. J.; Simpson, T. J. (2019): Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi., Chemical Science 2019, 10(1), 233-238
DOI: 10.1039/c8sc03778g

Ullah, S.; Seidel, K.; Tuerkkan, S.; Warwas, D. P.; Dubich, T.; Rohde, M.; Hauser, H.; Behrens, P.; Kirschning, A.; Koester, M.; et al. (2019): Macrophage entrapped silica coated superparamagnetic iron oxide particles for controlled drug release in a 3D cancer model., Journal of Controlled Release 2019, 294, 327-336
DOI: 10.1016/j.jconrel.2018.12.040

Wang H, Stahl F, Scheper T, Steffens M, Warnecke A, Zeilinger C (2019): Microarray-based screening system identifies temperature-controlled activity of Connexin 26 that is distorted by mutations. Sci Rep. 9, 13543
DOI: 10.1038/s41598-019-49423-3

Wang, Chongqing, Becker, Kevin, Pfuetze, Sebastian, Kuhnert, Eric, Stadler, Marc, Cox, Russell J., Skellam, Elizabeth (2019): Investigating the Function of Cryptic Cytochalasan Cytochrome P450 Monooxygenases Using Combinatorial Biosynthesis, ORGANIC LETTERS, 2019, 21
DOI: 10.1021/acs.orglett.9b03372
ISBN: 8756-8760

Wang, Chongqing, Hantke, Verena, Cox, Russell J., Skellam, Elizabeth (2019): Targeted Gene Inactivations Expose Silent Cytochalasans in Magnaporthe grisea NI980, ORGANIC LETTERS, 2019, 21
DOI: 10.1021/acs.orglett.9b01344

Warnecke A, Kirschning A, Landsberg D, Zeilinger C (2019): Hsp90: a target for susceptibilities and substitutions in biotechnological and medicinal application. Heat Shock Protein 90 in Human Diseases and Disorders, Ed Asea, Alexzander AA, Kaur, Punit (Eds.)
DOI: 10.1007/978-3-030-23158-3

Warnecke A.; Kirschning A.; Landsberg D.; Zeilinger C. (2019): C Hsp90: a target for susceptibilities and substitutions in biotechnological and medicinal application.

Yang, Xiao-Long, Friedrich, Steffen, Yin, Sen, Piech, Oliver, Williams, Katherine, Simpson, Thomas J., Cox, Russell J. (2019): Molecular basis of methylation and chain-length programming in a fungal iterative highly reducing polyketide synthase, CHEMICAL SCIENCE, 2019, 10
DOI: 10.1039/c9sc03173a
ISBN: 8478-8489

Alizadeh H, Davoodi J, Zeilinger C, Rafii-Tabar H. (2018): Molecular dynamics simulation of the thermosensitivity of the human connexin 26 hemichannel, Chemical Physics, 500, 7–14
DOI: 10.1016/j.chemphys.2017.11.002

Alizadeh, H.; Davoodi, J.; Zeilinger C.; Rafii-Tabar H. (2018): Molecular dynamics simulation of the thermosensitivity of the human connexin 26 hemichannel, Chemical Physics 2018, 500, 7-14
DOI: 10.1016/j.chemphys.2017.11.002

de Mattos-Shipley, K. M. J.; Greco, C.; Heard, D. M.; Hough, G.; Mulholland, N. P.; Vincent, J. L.; Micklefield, J.; Simpson, T. J.; Willis, C. L.; Cox, R. J.; et al. (2018): The cycloaspeptides: Uncovering a new model for methylated nonribosomal peptide biosynthesis., Chemical Science 2018, 9(17), 4109-4117
DOI: 10.1039/c8sc00717a

He Y., Wang B., Chen W., Cox R. J., He J. and Chen F. (2018): Recent advances in reconstruction microbial seconday metabolites biosynthesis in Aspergillus spp., Biotechnol. 36 (3), 2018 739-783
DOI: 10.1016/j.biotechadv.2018.02.001

Kirschning, A.; Dibbert, N.; Draeger, G. (2018): Chemical Functionalization of Polysaccharides-Towards Biocompatible Hydrogels for Biomedical Applications., Chem-Eur. J. 2018, 24(6), 1231-1240
DOI: 10.1002/chem.201701906

Kuhnert, E.; Li Y.; Lan, N.; Yue, Q.; Chen, L.; Cox, R. J.; An, Z.; Yokoyama, K.; Bills, G. F. (2018): Enfumafungin synthase represents a novel lineage of fungal triterpene cyclases., Environmental Microbiology 2018, 20(9,SI), 3325-3342
DOI: 10.1111/1462-2920.14333

Lercher, L.; Danilenko, N.; Kirkpatrick, J.; Carlomagno, T. (2018): Structural characterization of the Asf1-Rtt109 interaction and its role in histone acetylation., Nucleic Acids Res 2018, 46(5), 2279-2289
DOI: 10.1093/nar/gkx1283

Li, J.; Xing, J.; Luecke, D.; Luebken, D.; Millbrodt, L.; Plentz, R. R.; Kalesse, M. (2018): The Structure Elucidation of Haprolid., Synthesis-Stuttgart 2018, 50(3), 529-538
DOI: 10.1055/s-0036-1591836

Luecke, D.; Linne, Y.; Hempel, K.; Kalesse, M. (2018): Total Synthesis of Pericoannosin A., Organic Letters 2018, 20(15), 4475-4477
DOI: 10.1021/acs.orglett.8b01768

Marchanka, A.; Kreutz, C.; Carlomagno, T. (2018): Isotope labeling for studying RNA ba solid-state NMR spectroscopy., Journal of Biomolecular NMR 2018, 71(3,SI), 151-164
DOI: 10.1007/s10858-018-0180-7

Marchanka, A.; Stanec, J.; Pintacuda, G.; Carlomagno, T. (2018): Rapid access to RNA resonances by proton-detected solid-state NMR at > 100 kHz MAS., Chemical Communications 2018, 54(65), 8972-8975
DOI: 10.1039/c8cc04437f

Mattos-Shipley K., Lebe K. E., Han L.-C., Iqbal Z., Bailey A., Willis C., Simpson T. and Cox R. J. (2018): Strobilurin Biosynthesis in Basidiomycete Fungi, Nature Commun. 9, 2018 3940
DOI: 10.1038/s41467-018-06202-4

Mohammadi-Ostad-Kalayeh S, Stahl F, Scheper T, Kock K, Herrmann C, Batista FAH, Borges JC, Sasse F, Eichner S, Ongouta J, Zeilinger C, Kirschning A (2018): Heat shock proteins revisited using a mutasynthetically generated reblastatin library for comparing the inhibition of human with Leishmania Hsp90s. ChemBioChem, 19, 1–14
DOI: 10.1002/cbic.201700616

Oberhauser, C.; Harms, V.; Seidel, K.; Schroeder, B.; Ekramzadeh, K.; Beutel, S.; Winkler, S.; Lauterbach, L.; Dickschat, J. S.; Kirschning, A. (2018): Exploiting the Synthetic Potential of Sesquiterpene Cyclases for Gnerating Unnatural Terpenoids., Angew. Chem. Int. Edit. 2018, 57(36), 11802-11806
DOI: 10.1002/anie.201805526

Podrezova, E. V.; Larkina, M. S.; Belousov, M. V.; Kirschning, A.; Zhdankin, V. V.; Yusubov, M. S. (2018): Expedient Synthesis of Long-Chain omega-Substituted Fatty Acids and Esters from Cyclic Ketones using Iodine and Hydrogen Peroxide., Synthesis-Stuttgart 2018, 50(20), 4081-4088
DOI: 10.1055/s-0036-1591598

Schmitt H, Roemer A, Zeilinger C, Salcher R, Durisin M, Staecker H, Lenarz T, Warnecke A. (2018): Heat Shock Proteins in Human Perilymph: Implications for Cochlear Implantation. Otol Neurotol. 39, 37-44
DOI: 10.1097/MAO.0000000000001625

Schmitt, H.; Roemer, A.; Zeilinger, C.; Salcher, R.; Durisin, M.; Staecker, H.; Lenarz, T.; Warnecke, A. (2018): Heat Shock Proteins in Human Perilymph: Implications for Cochlear Implantation., Otology & Neurotology 2018, 39(1), 37-44
DOI: 10.1097/MAO.0000000000001625

Schor, R.; Cox, R. J. (2018): Classic fungal natural products in the genomic age: the molecular legacy of Harold Raistrick., Nat. Prod. Rep. 2018, 35(3), 230-256
DOI: 10.1039/c8np00021b

Schor, R.; Schotte, C.; Wibberd, D.; Kalinowski, J.; Cox, R. J. (2018): Three previously unrecognised classes of biosynthetic enzymes revealed during the production of xenovulene A., Nature Communications 2018, 9
DOI: 10.1038/s41467-018-04364-9

Sommer, H.; Braun, M.; Schroeder, B.; Kirschning, A. (2018): 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one (ETFBO), a Versatile Precursor for Trifluoromethyl-Substituted Heteroarenes - a Short Synthesis of Celebrex(R) (Celecoxib)., Synlett 2018, 29(1), 121-125
DOI: 10.1055/s-0036-1589097

Stempel, E.; Kaml, R. F.-X.; Budisa, N.; Kalesse, M. (2018): Painting argyrins blue: Negishi cross-coupling for synthesis of deep-blue tryptophan analogue beta-(1-azulenyl)-L-alanine and its incorporation into argyrin C., Bioorgan. Med. Chem. 2018, 26(19), 5259-5269
DOI: 10.1016/j.bmc.2018.03.037

Surup, F.; Kuhnert, E.; Boehm, A.; Pendzialek, T.; Solga, D.; Wiebach, V.; Engler, H.; Berkessel, A.; Stadler, M.; Kalesse, M. (2018): The Rickiols: 20-, 22-, and 24-membered Macrolides from the Ascomycete Hypoxylon rickii., Chem-Eur. J. 2018, 24(9), 2200-2213
DOI: 10.1002/chem.201704928

Yue Q, Stahl F, Plettenburg O, Kirschning A, Warnecke A, Zeilinger C (2018): The Noncompetitive Effect of Gambogic Acid Displaces Fluorescence-Labeled ATP but Requires ATP for Binding to Hsp90/HtpG. Biochemistry. 57, 2601-2605
DOI: 10.1021/acs.biochem.8b00155

Yue, Q.; Stahl, F.; Plettenburg, O.; Kirschning, A.; Warnecke, A.; Zeilinger, C. (2018): The Noncompetitive Effect of Gambogic Acid Displaces Fluorescence-Labeled ATP but Requires ATP for Binding to Hsp90/HtpG., Biochemistry 2018, 57(18), 2601-2605
DOI: 10.1021/acs.biochem,8b00155

Ammermann, J.; Schmidt, T.; Donner, J.; Reck, M.; Dalton, M.; Stumpp, N.; Stiesch, M.; Wagner-Doebler, I.; Kirschning, A. (2017): The carolactam strategy is ineffective: Synthesis and bioological evaluation of carolactam., Org. Biomol. Chem. 2017, 15(40), 8553-8558
DOI: 10.1039/c7ob02060krsc.li/obc

Ceylan, S.; Law, H. C.-H.; Kirschning, A.; Toy, P. H. (2017): Organocatalytic Alkyne Isomerizations under Flow Conditions Using Heterogeneous Bifunctional Polystyrene Bearing Phosphine and Phenol Groups., Synthesis-Stuttgart 2017, 49(1), 145-150
DOI: 10.1055/s-0036-1588589

Codutti, L.; Grimaldi, M.; Carlomagno, T. (2017): Structure-Based Design of Scaffolds Targeting PDE10A by INPHARMA-NMR., J. Chem. Inf. Model. 2017, 57 (6), 1488-1498
DOI: 10.1021/acs.jcim.7b00246

Donner, J.; Reck, M.; Bunk, D.; Jarek, M.; App, C. B.; Meier-Kolthoff, J. P.; Overmann, J.; Mueller, R.; Kirschning, A.; Wagner-Doebler, I. (2017): The Biofilm Inhibitor Carolacton Enters Gram-Negative Cells: Studies Using a TolC-Deficient Strain of Escherichia coli., Msphere 2017, 2(5)
DOI: 10.1128/mSphereDirect.00375-17

Essoung, F. R. E.; Mba'ning, B. M.; Mohamed, S. A.; Lwande, W.; Ngouela, S. A.; Tsamo, E.; Chhabra, S. C.; Hassanali, A.; Cox, R. J. (2017): Welwitschianalol A and B, two cyclohexene derivatives and other insecticidal constituents of Caesalpinia welwitschiana (Oliv.) Brenan., Phytochemistry Letters 2017, 22, 81-86
DOI: 10.1016/j.phytol.2017.09.010

Feng, J.; Zhang, P.; Cui, Y.; Li, K.; Qiao, X.; Zhang, Y.-T.; Li, S.-M.; Cox, R. J.; Wu, B.; Ye, M.; et al. (2017): Regio- and Stereospecific O-Glycosylation of Phenolic Compounds Catalyzed by a Fungal Glycosyltransferase from Mucor hiemalis., Advanced Synthesis & Catalysis 2017, 359(6), 995-1006
DOI: 10.1002/adsc.201601317

Gao, S.-S.; Wang, L.; Song, Z.; Hothersall, J.; Stevens, E. R.; Connolly, J.; Winn, P. J.; Cox, R. J.; Crump, M. P.; Race, P. R.; et al. (2017): Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics., Angew. Chem. Int. Edit. 2017, 56(14), 3930-3934
DOI: 10.1002/anie.201611590

Karaca, E.; Rodrigues, J. P. G. L. M.; Graziadei, A.; Bonvin, A. M. J. J.; Carlomagno, C. (2017): M3: an integrative framework for structure determination of molecular machines, Nature Methods 2017, 14 897-902
DOI: 10.1038/nmeth.4392

Kipke, A.; Schoening, K.-U.; Yusubov, M.; Kirschning, A. (2017): TEMPO-Mediated Oxidative Deformylation of Aldehydes: Applications in the Synthesis of Polyketide Fragments., Eur. J. Org. Chem. 2017, 46, 6906-6913
DOI: 10.1002/ejoc.201701349

Liddle, E.; Scott, A.; Han, C.; Ivison, D.; Simpson, T. J.; Willis, C. L.; Cox, R. J. (2017): In vitro kinetic study of the squalestatin tetraketide synthase dehydratase reveals the stereochemical course of a fungal highly reducing polyketide synthase., Chemical Communications 2017, 53(10), 1727-1730
DOI: 10.1039/c6cc10172k

Mohammadi-Ostad-Kalayeh S, Hrupins V, Helmsen S, Ahlbrecht A, Stahl F, Scheper T, Preller M, Surup F, Stadler M, Kirschning A, Zeilinger C (2017): Development of a microarray-based assay for efficient testing of new HSP70/DnaK inhibitors. Bioorg Med Chem, pii: S0968-0896(17), 31487-31486
DOI: 10.1016/j.bmc.2017.10.003

Mohammadi-Ostad-Kalayeh, S.; Hrupins, V.; Helmsen, S.; Ahlbrecht, C.; Stahl, F.; Scheper, T.; Preller, M.; Surup, F.; Stadler, M.; Kirschning, A.; et al. (2017): Development of a microarray-based assay for efficient testing of new HSP70/DnaK inhibitors., Bioorgan. Med. Chem. 2017, 25(24), 6345-6352
DOI: 10.1016/j.bmc.2017.10.003

Moore, B. S.; Carter, G. T.; Broenstrup, M. (2017): Editorial: Are natural products the solution to antimicrobial resistance?, Nat. Prod. Rep. 2017, 34(7), 685-686
DOI: 10.1039/c7np90026k

Poock, C.; Kalesse, M. (2017): Total Synthesis of Nannocystin Ax., Organic Letters 2017, 19(17), 4536-4539
DOI: 10.1021/acs.orglett.7b02112

Roberts, D. M.; Bartel, C.; Scott, A.; Ivison, D.; Simpson, T. J.; Cox, R. J. (2017): Substrate selectivity of an isolated enoyl reductase catalytic domain from an iterative highly reducing fungal polyketide synthase reveals key components of programming., Chemical Science 2017, 8(2), 1116-1126
DOI: 10.1039/c6sc03496a

Scherer, S.; Wollrab, E.; Codutti, L.; Carlomagno, T.; Gomes da Costa, S.; Volkmer, A.; Bronja, A.; Schmtz, O. J.; Ott, A. (2017): Chemical Analysis of a “Miller-Type” Complex Prebiotic Broth, Orig. Life Evol. Biosph. 2017, 47 381-403
DOI: /10.1007/s11084-016-9528-8

Seidel, K.; Balakrishnan, A.; Alexiou, C.; Janko, C.; Komoll, R.-M.; Wand, L.-L.; Kirschning, A.; Ott, M. (2017): Synthesis of Magnetic-Nanoparticle/Ansamitocin Conjugates-Inductive Heating Leads to Decreased Cell Proliferation In Vitro and Attenuation of Tumour Growth In Vivo., Chem-Eur. J. 2017, 23(50,SI), 12326-12337
DOI: 10.1002/chem.201701491

Sharma R, Mohammadi-Ostad-Kalayeh S, Stahl F, Zeilinger C, Dräger G, Kirschning A, Ravikumar PC (2017): Two new labdane diterpenoids and one new β lactam compound from the aerial part of Roylea cinerea Phytochem. Lett, 19, 101–107
DOI: 10.1016/j.phytol.2016.12.013

Sharma, R.; Mohammadi-Ostada-Kalayeh, S.; Stahl, F.; Zeilinger, C.; Draeger, G.; Kirschning, A.; Ravikumar, P. C. (2017): Two new labdane diterpenoids and one new beta-lactam from the aerial parts of Roylea cinerea., Phytochemistry Letters 2017, 19, 101-107
DOI: 10.1016/j.phytol.2016.12.013

Trenti, F.; Cox, R. J. (2017): Structural Revision and Biosynthesis of the Fungal Phytotoxins Phyllostictines A and B., J. Nat. Prod. 2017, 80(5), 1235-1240
DOI: 10.1021/acs.jnatprod.7b00183

W. Chen, R. Chen, Q. Liu, Y. He, K. He, X. Ding, L. Kang, X. Guo, N. Xie, Y. Zhou, Y. Lu, R. J. Cox, I. Molnar, M. Li, Y. Shao, F. Chen (2017): Orange, red, yellow: biosynthesis of azaphilone pigments in Monascus fungi, Chemical Science 2017
DOI: 10.1039/c7sc00475c

Wang, L.-L.; Balakrishnan, A.; Bigall, N.-C.; Candito, D.; Miethe, J. F.; Seidel, K.; Xie, Y.; Ott, M.; Kirschning, A. (2017): A Bio-Chemosynthetic Approach to Superparamagnetic Iron Oxide-Ansamitocin Conjugates for use in Magnetic Drug Targeting., Chem-Eur. J. 2017, 23(10), 2265-2270
DOI: 10.1002/chem.201604903

Wang, L.-L.; Candito, D.; Draeger, G.; Herrmann, J.; Mueller, R.; Kirschning, A. (2017): Harnessing a p-Quinone Methide Intermediate in the Biomimetic Total Synthesis of the Highly Active Antibiotic 20-Deoxy-Elansolid B1., Chem-Eur. J. 2017, 23(22), 5291-5298
DOI: 10.1002/chem.201605884

Wang, L.-L.; Candito, D.; Draeger, G.; Kirschning, A. (2017): Synthetic Studies Probing Elansolid Biosynthesis: A para-Quinone-Methide-Triggered Intramolecular Diels-Alder Reaction., Eur. J. Org. Chem. 2017, 37, 5582-5591
DOI: 10.1002/ejoc.201701125

Wang, L.-L.; Kirschning, A. (2017): Total synthesis of elansolids B1 and B2., Beilstein Journal of Organic Chemistry 2017, 13, 1280-1287
DOI: 10.3762/bjoc.13.124

Williams K., Szwalbe A. J., Dickson C., Desson T. R., Mulholland N. P., Vincent J. L., Clough J. M., Bailey A. M., Butts C. P., Willis C. L., Simpson T. J., Cox R. J. (2017): Genetic and Chemical Characterisation of the Cornexistin Pathway Provides Further Insight into Maleidride Biosynthesis, Chem. Commun, 2017, in press
DOI: 10.1039/C7CC03303F

Witte, S. N. R.; Hug, J. J.; Geraldy, M. N. E.; Mueller, R.; Kalesse, M. (2017): Biosynthesis and Total Synthesis of Pyrronazol B: a Secondary Metabolite from Nannocystis pusilla., Chem. Eur. J. 2017, 23(63), 15917-15921
DOI: 10.1002/chem.201703782

Yusubov, M. S.; Postnikov, P. S.; Yusubova, R. Y.; Yoshimura, A.; Juerjens, G.; Kirschning, A.; Zhdankin, V. V. (2017): 2-Iodoxybenzoic Acid Tosylates: The Alternative to Dess-Martin Periodiane Oxidizing Reagents., Advanced Synthesis & Catalysis 2017, 359(18), 3207-3216
DOI: 10.1002/adsc.201700776

Bowman, A.; Lercher, L.; Singh, H. R.; Zinne, D.; Timinszky, G.; Carlomagno, T.; Ladurner, A. G. (2016): The histone chaperone sNASP binds a conserved peptide motif within the globular core of histone H3 through its TPR repeats., Nucleic Acids Res. 2016, 44(7), 3105-3117
DOI: 10.1093/nar/gkv1372

Busch, T.; Draeger, G.; Kunst, E.; Benson, H.; Sasse, F.; Siems, K.; Kirschning, A. (2016): Synthesis and antiproliferative activity of new tonantzitlolone-derived diterpene derivatives., Org. Biomol. Chem. 2016, 14(38), 9040-9045
DOI: 10.1039/c6ob01697a

Dibbert, N.; Krause, A.; Rios-Camacho, J.-C.; Gruh, I.; Kirschning, A.; Draeger, G. (2016): A Synthetic Toolbox for the In Situ Formation of Functionalized Homo- and Heteropolysaccharide-Based Hydrogel Libraries., Chem-Eur. J. 2016, 22(52), 18777-18786
DOI: 10.1002/chem.201603748

Donner, J.; Reck, M.; Bergmann, S.; Kirschning, A.; Mueller, R.; Wagner-Doebler, I. (2016): The biofilm inhibitor Carolacton inhibits planktonic growth of virulent pneumococci via a conserved target., Scientific Reports 2016, 6
DOI: 10.1038/srep29677

Gerstmann, L.; Kalesse, M. (2016): Total Synthesis of Aetheramide A., Chem-Eur. J. 2016, 22(32), 11210-11212
DOI: 10.1002/chem.201602682

Gille, F.; Kirschning, A. (2016): Studies on the synthesis of peptides containing dehydrovaline and dehydroisoleucine based on copper-mediated enamide formation., Beilstein Journal of Organic Chemistry 2016, 12, 564-570
DOI: 10.3762/bjoc.12.55

Graziadei, A.; Masiewicz, P.; Lapinaite, A.; Carlomagno, T. (2016): Archaea box C/D enzymes methylate two distinct substrate rRNA sequences with different efficiency, RNA. 2016, 22, 764-772
DOI: 10.1261/rna.054320.115

Hartwig, J.; Kirschning, A. (2016): Flow Synthesis in Hot Water: Synthesis of the Atypical Antipsychotic Iloperidone., Chem-Eur J. 2016, 22(9), 3044-3052
DOI: 10.1002/chem.201504409

Kempf, H.; Olmer, R.; Haase, A.; Franke, A.; Bolesani, E.; Schwanke, K.; Robles-Diaz, D.; Coffee, M.; Goehring, G.; Draeger, G.; et al. (2016): Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells., Nature Communications 2016, 7
DOI: 10.1038/ncomms13602

Kozak, S.; Lercher, L.; Karanth, M. N.; Meijers, R.; Carlomagno, T.; Boivin, S. (2016): Optimization of protein samples for NMR using thermal shift assays., Journal of Biomolecular NMR 2016, 64(4), 281-289
DOI: 10.1007/s10858-016-0027-z

Kuehne, C.; Singer, H. M.; Grabisch, E.; Codutti, L.; Carlomagno, T.; Scrima, A.; Erhardt, M. (2016): RflM mediates target specificity of the RcsCDB phosphorelay system for transcriptional repression of flagellar synthesis in Salmonella enterica., Mol. Microbiol. 2016, 101(5), 841-855
DOI: 10.1111/mmi.13427

Miller, T. C. R.; Simon, B.; Rybin V.; Grötsch, H.; Curtet, S.; Khochbin, S.; Carlomagno, T.; Müller C. W. (2016): A bromodomain–DNA interaction facilitates acetylation-dependent bivalent nucleosome recognition by the BET protein BRDT, Nat. Commun. 2016, 7
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Pfeffer, T. J.; Sasse, F.; Schmidt, C. F.; Lakaemper, S.; Kirschning, A.; Scholz, T. (2016): The natural diterpene tonantzitlolone A and its synthetic enantiomer inhibit cell proliferation and kinesin-5 function., European Journal of Medicinal Chemistry 2016, 112, 164-170
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Poggenburg, C.; Mikutta, R.; Sander, M.; Schippers, A.; Marchanka, A.; Dohrmann, R.; Guggenberger, G. (2016): Microbial reduction of ferrihydrite-organic matter coprecipitates by Shewanella putrefaciens and Geobacter metallireducens in comparison to mediated electrochemical reduction., Chemical Geology 2016, 447, 133-147
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Wollrab, E.; Scherer, S.; Abriet, F.; Carré, V.; Carlomagno, T.; Codutti, L.; Ott, A. (2016): Chemical Analysis of a "Miller-Type" Complex Prebiotic Broth: Part I: Chemical Diversity, Oxygen and Nitrogen Based Polymers., Orig. Life Evol. Biosph. 2016, 46 (2-3), 149-169
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Bluhm, N.; Kalesse, M. (2015): Synthesis of a C20-Deoxygenated Spirangien Derivative for Target Identification., Synlett 2015, 26(6), 797-801
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Bulyszko, I.; Draeger, G.; Klenge, A.; Kirschning, A. (2015): Evaluation of the Synthetic Potential of an AHBA Knockout Mutant of the Rifamycin Producer Amycolatopsis mediterranei., Chem-Eur. J. 2015, 21(52), 19231-19242
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Franke, J.; Bock, M.; Dehn, R.; Fohrer, J.; Mhaske, S. B.; Migliorini, A.; Kanakis, A. A.; Jansen, R.; Herrmann, J.; Mueller, R.; et al. (2015): Total and Semi-Syntheses of Antimicrobial Thuggacin Derivatives., Chem-Eur. J. 2015, 21(11), 4272-4284
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Hartwig, J.; Kirschning, A. (2015): Iterative SynthesesThe Gateway to New Automation Protocols., Angew. Chem. Int. Edit. 2015, 54(36), 10412-10414
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Hermane, J.; Bulyszko, I.; Eichner, S.; Sasse, F.; Collisi, W.; Poso, A.; Schax, E.; Walter, J.-G.; Scheper, T.; Kock, K.; et al. (2015): New, Non-quinone Fluorogeldanamycin Derivatives Strongly Inhibit Hsp90., Chembiochem 2015, 16(2), 302-311
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Juerjens, G.; Kirschning, A.; Candito, D. A. (2015): Lessons from the Synthetic Chemist Nature., Nat. Prod. Rep. 2015, 32(5), 723-737
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Kirschning, A.; Reydon, T. A. C. (2015): Is organic chemistry science - and does this question make any sense at all?, Beilstein Journal of Organic Chemistry 2015, 11, 893-896
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Lu, H.-H.; Hinkelmann, B.; Tautz, T.; Li, J.; Sasse, F.; Franke, R.; Kalesse, M. (2015): Paleo-soraphens: chemical total syntheses and biological studies., Org. Biomol. Chem. 2015, 13(29), 8029-8036
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Mohammadi-Ostad-Kalayeh, S.; Schax, E.; Walter, J. G.; Scheper, T.; Hermane, J.; Kirschning, A.; Borges, J. C.; Zeilinger, C. (2015): Targetomics, microarray-based screening for the identification of new drugs against Leishmania braziliensis., Febs Journal 2015, 282(1,SI), 272

Moreno, M.; Elgaher, W. A. M.; Herrmann, J.; Schlaeger, N.; Hamed, M. M.; Baumann, S.; Mueller, R.; Hartmann, R. W.; Kirschning, A. (2015): Synthesis and Biological Evaluation of Cystobactamid 507: A Bacterial Topoisomerase Inhibitor from Cystobacter sp., Synlett 2015, 26(9), 1175-1178
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Naini, A.; Fohrer, J.; Kalesse, M. (2015): The Synthesis of Desepoxy-Isotedanolide - A Potential Biosynthetic Precursor of Tedanolide., Eur. J. Org. Chem. 2015, 20, 4400-4411
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Naini, A.; Muthukumar, Y.; Raja, A.; Franke, R.; Harrier, I.; Smith, A. B., III; Lee, D.; Taylor, R. E.; Sasse, F.; Kalesse, M. (2015): The Synthesis and Biological Evaluation of Desepoxyisotedanolide and a Comparison with Desepoxytedanolide., Angew. Chem. Int. Edit. 2015, 54(23), 6935-6939
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Stumpp, N.; Premnath, P.; Schmidt, T.; Ammermann, J.; Draeger, G.; Reck, M.; Jansen, R.; Stiesch, M.; Wagner-Doebler, I.; Kirschning, A. (2015): Synthesis of new carolacton derivatives and their activity against biofilms of oral bacteria., Org. Biomol. Chem. 2015, 13(20), 5765-5774
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Chaudhuri, S. R.; Hartwig, J.; Kupracz, L.; Kodanek, T.; Wegner, J.; Kirschning, A. (2014): Oxidations of Allylic and Benzylic Alcohols under Inductively-Heated Flow Conditions with Gold-Doped Superparamagnetic Nanostructured Particles as Catalyst and Oxygen as Oxidant., Advanced Synthesis & Catalysis 2014, 356(17), 3530-3538
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Geist, E.; Kirschning, A.; Schmidt, T. (2014): sp(3)-sp(3) Coupling reactions in the synthesis of natural products and biologically active molecules., Nat. Prod. Rep. 2014, 31(4), 441-448
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Gieseler, M. T.; Kalesse, M. (2014): Synthesis of Angiolam A., Organic Letters 2014, 16(2), 548-551
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Harmrolfs, K.; Mancuso, L.; Drung, B.; Sasse, F.; Kirschning, A. (2014): Preparation of new alkyne-modified ansamitocins by mutasynthesis., Beilstein Journal of Organic Chemistry 2014, 10, 535-543
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Hartmann, O.; Kalesse, M. (2014): The Structure Elucidation and Total Synthesis of beta-Lipomycin., Angew. Chem. Int. Edit. 2014, 53(28), 7335-7338
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Jirawutthiwongchai, J.; Draeger, G.; Chirachanchai, S. (2014): Rapid Hybridization of Chitosan-Gold-Antibodies via Metal-free Click in Water-based Systems: A Model Approach for Naked-eye Detectable Antigen Sensors., Macromolecular Rapid Communications 2014, 35(13), 1204-1210
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Juerjens, G.; Kirschning, A. (2014): Pushing Flow Chemistry to New Limits: Development of a Flow Process towards Spirangien A., Chemcatchem 2014, 6(10), 2798-2800
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Juerjens, G.; Kirschning, A. (2014): Synthesis of a Cytotoxic Ansamycin Hybrid., Organic Letters 2014, 16(11), 3000-3003
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Kalesse, M.; Cordes, M.; Symkenberg, G.; Lu, H.-H. (2014): The vinylogous Mukaiyama aldol reaction(VMAR) in natural product synthesis., Nat. Prod. Rep. 2014, 31(4), 563-594
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Schax E, Walter JG, Märzhäuser H, Stahl F, Scheper T, Agard DA, Eichner S, Kirschning A, Zeilinger C (2014): Microarray-based screening of heat shock protein inhibitors. J Biotechnol. 180, 1-9
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Schax, E.; Walter, J.-G.; Mazhauser, H.; Stahl, F.; Scheper, T.; Agard, D. A.; Eichner, S.; Kirschning, A.; Zeilinger, C. (2014): Microarray-based screening of heat shock protein inhibitors., Journal of Biotechnology 2014, 180, 1-9
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Symkenberg, G.; Kalesse, M. (2014): Structure Elucidation and Total Synthesis of Kulkenon., Angew. Chem. Int. Edit. 2014, 53(7), 1795-1798
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Weber, A.; Dehn, R.; Schlaeger, N.; Dieter, B.; Kirschning, A. (2014): Total Synthesis of the Antibiotic Elansolid B1., Organic Letters 2014, 16(2), 568-571
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Weiss, E.; Dutta, B.; Kirschning, A.; Abu-Reziq, R. (2014): BMIm-PF6@SiO2 Microcapsules: Particulated Ionic Liquid as A New Material for the Heterogenization of Catalysts., Chemistry of Materials 2014, 26(16), 4781-4787
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